Tracking the Emergence and Dissemination of a <i>bla</i> <sub>NDM-23</sub> Gene in a Multidrug Resistance Plasmid of Klebsiella pneumoniae-Reference-Cited by-同舟云学术

Tracking the Emergence and Dissemination of a bla _NDM-23 Gene in a Multidrug Resistance Plasmid of Klebsiella pneumoniae

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

García-González Neris¹²^ORCID,Beamud Beatriz¹²^ORCID,Fuster Begoña³,Giner Salvador⁴,Domínguez Maria Victoria⁵,Sánchez Antonia⁶,Sevilla Jordi¹,Coque Teresa M.⁷⁸^ORCID,Gimeno Concepción³,González-Candelas Fernando¹²⁹^ORCID,García-González Neris,González-Candelas Fernando,Fuster Begoña,Tormo Nuria,Salvador Carme,Gimeno Concepción,Domínguez Victoria,Giner Salvador,Colomina Javier,Navarro David,Martínez Llúcia,Burgos Antonio,Martínez Olalla,Gomila-Sard Barbara,Moreno Rosario,Vidal Inmaculada,Sánchez Antonia,Rodriguez Juan Carlos,Sánchez-Hellín Victoria

Affiliation:

1. Institute for Integrative Systems Biology (CSIC-UV), Valencia, Spain

2. Joint Research Unit Infection and Public Health FISABIO-University of Valencia, Institute for Integrative Systems Biology (UV-CSIC), Valencia, Spain

3. Microbiology Service, General University Hospital, Valencia, Spain

4. Microbiology Service, Hospital La Fe, Valencia, Spain

5. Microbiology Service, Hospital Arnau de Vilanova, Valencia, Spain

6. Microbiology Service, General University Hospital, Alicante, Spain

7. Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain

8. Network Research Centre for Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain

9. Network Research Centre for Epidemiology and Public Health, Madrid, Spain

Abstract

At a time when antimicrobial resistance has become one of the biggest concerns worldwide, the emergence of novel alleles and extremely drug-resistant plasmids is a threat to public health worldwide, especially when they produce carbapenem resistance in one of the most problematic pathogens, such as Klebsiella pneumoniae . We used genomic epidemiology to describe the emergence of a novel NDM-23 allele and identify it in a MDR plasmid that has disseminated through a K. pneumoniae ST437 clone in several hospitals in Spain.

Funder

EC | European Regional Development Fund

Ministerio de Ciencia e Innovación

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02585-22

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