Tracking the Emergence and Dissemination of a <i>bla</i> <sub>NDM-23</sub> Gene in a Multidrug Resistance Plasmid of Klebsiella pneumoniae-Reference-Cited by-同舟云学术

Tracking the Emergence and Dissemination of a bla _NDM-23 Gene in a Multidrug Resistance Plasmid of Klebsiella pneumoniae

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

García-González Neris¹²^ORCID,Beamud Beatriz¹²^ORCID,Fuster Begoña³,Giner Salvador⁴,Domínguez Maria Victoria⁵,Sánchez Antonia⁶,Sevilla Jordi¹,Coque Teresa M.⁷⁸^ORCID,Gimeno Concepción³,González-Candelas Fernando¹²⁹^ORCID,García-González Neris,González-Candelas Fernando,Fuster Begoña,Tormo Nuria,Salvador Carme,Gimeno Concepción,Domínguez Victoria,Giner Salvador,Colomina Javier,Navarro David,Martínez Llúcia,Burgos Antonio,Martínez Olalla,Gomila-Sard Barbara,Moreno Rosario,Vidal Inmaculada,Sánchez Antonia,Rodriguez Juan Carlos,Sánchez-Hellín Victoria

Affiliation:

1. Institute for Integrative Systems Biology (CSIC-UV), Valencia, Spain

2. Joint Research Unit Infection and Public Health FISABIO-University of Valencia, Institute for Integrative Systems Biology (UV-CSIC), Valencia, Spain

3. Microbiology Service, General University Hospital, Valencia, Spain

4. Microbiology Service, Hospital La Fe, Valencia, Spain

5. Microbiology Service, Hospital Arnau de Vilanova, Valencia, Spain

6. Microbiology Service, General University Hospital, Alicante, Spain

7. Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain

8. Network Research Centre for Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain

9. Network Research Centre for Epidemiology and Public Health, Madrid, Spain

Abstract

At a time when antimicrobial resistance has become one of the biggest concerns worldwide, the emergence of novel alleles and extremely drug-resistant plasmids is a threat to public health worldwide, especially when they produce carbapenem resistance in one of the most problematic pathogens, such as Klebsiella pneumoniae . We used genomic epidemiology to describe the emergence of a novel NDM-23 allele and identify it in a MDR plasmid that has disseminated through a K. pneumoniae ST437 clone in several hospitals in Spain.

Funder

EC | European Regional Development Fund

Ministerio de Ciencia e Innovación

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02585-22

Reference46 articles.

1. Characterization of a New Metallo-β-Lactamase Gene, bla NDM-1 , and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India

2. The global epidemiology of carbapenemase-producing Enterobacteriaceae

3. Structure, Genetics and Worldwide Spread of New Delhi Metallo-β-lactamase (NDM): a threat to public health

4. NDM Metallo-β-Lactamases and Their Bacterial Producers in Health Care Settings

5. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Prevalence of Antibiotic Resistance Phenotypes and Genotypes in Multidrug-Resistant Bacterial Isolates from the Academic Hospital of Jaén, Spain;Antibiotics;2024-05-09

2. First detection in Spain of NDM-1-producing Pseudomonas aeruginosa in two patients transferred from Ukraine to a university hospital;Journal of Global Antimicrobial Resistance;2024-03

3. Genomic analysis of the initial dissemination of carbapenem-resistant Klebsiella pneumoniae clones in a tertiary hospital;Microbial Genomics;2023-06-05