PNPase and RhlB Interact and Reduce the Cellular Availability of Oxidized RNA in <i>Deinococcus radiodurans</i>-Reference-Cited by-同舟云学术

PNPase and RhlB Interact and Reduce the Cellular Availability of Oxidized RNA in Deinococcus radiodurans

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Han Runhua¹,Jiang Jessie¹,Fang Jaden¹,Contreras Lydia M.¹²

Affiliation:

1. McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas, USA

2. Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA

Abstract

Oxidative RNA damage can be caused by oxidative stress, such as hydrogen peroxide, ionizing radiation, and antibiotic treatment. 8-oxo-7,8-dihydroguanine (8-oxoG), a major type of oxidized RNA, is highly mutagenic and participates in a variety of disease occurrences and development. Although several proteins have been identified to recognize 8-oxoG-modified RNA, the knowledge of how RNA oxidative damage is controlled largely remains unclear, especially in nonmodel organisms.

Funder

DOD | Defense Threat Reduction Agency

DOD | USAF | AMC | Air Force Research Laboratory

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02140-22

Reference64 articles.

1. Pathways of Oxidative Damage