Rapid Pathogen Identification in Aqueous Humor Samples by Combining Fc-MBL@Fe <sub>3</sub> O <sub>4</sub> Enrichment and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry Profiling-Reference-Cited by-同舟云学术

Rapid Pathogen Identification in Aqueous Humor Samples by Combining Fc-MBL@Fe ₃ O ₄ Enrichment and Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry Profiling

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Ren Jun¹,Yu Menghuan²,Gao Wenjin²,Ding Chuanfan²,Li Shengjie¹^ORCID,Yu Shaoning²,Cao Wenjun¹^ORCID

Affiliation:

1. Clinical Laboratory, Eye & ENT Hospital, Fudan University, Shanghai, China

2. Zhejiang Provincial Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis, Institute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang, China

Abstract

Fc-MBL@Fe 3 O 4 capture not only live bacteria in aqueous humor but also bacteria inactivated by antibiotics. Fc-MBL@Fe 3 O 4 combined with micro-LB broth culture significantly reduced the turnaround time (TAT) by more than half a day by shortening the time required for bacterial identification.

Funder

The Excellent Physician-Excellent Clinical Researcher Plan

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01767-22

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