Escherichia coli SPFH Membrane Microdomain Proteins HflKC Contribute to Aminoglycoside and Oxidative Stress Tolerance

Author:

Wessel Aimee K.1,Yoshii Yutaka1,Reder Alexander2,Boudjemaa Rym3,Szczesna Magdalena14,Betton Jean-Michel5,Bernal-Bayard Joaquin16,Beloin Christophe1ORCID,Lopez Daniel7,Völker Uwe2,Ghigo Jean-Marc1ORCID

Affiliation:

1. Institut Pasteur, Université de Paris-Cité, CNRS UMR6047, Genetics of Biofilms Laboratory, Paris, France

2. Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany

3. Abbelight, Cachan, France

4. Centre for Bacteriology Resistance Biology, Imperial College London, London, United Kingdom

5. Institut Pasteur, Université de Paris-Cité, UMR UMR6047, Stress adaptation and metabolism in enterobacteria, Paris, France

6. Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain

7. Universidad Autonoma de Madrid, Centro Nacional de Biotecnologia, Madrid, Spain

Abstract

Eukaryotic cells often segregate physiological processes in cholesterol-rich functional membrane microdomains. These domains are also called lipid rafts and contain proteins of the s tomatin, p rohibitin, f lotillin, and H flK/C (SPFH) superfamily, which are also present in prokaryotes but have been mostly studied in Gram-positive bacteria.

Funder

EC | Horizon 2020 Framework Programme

Agence Nationale de la Recherche

Fondation pour la Recherche Médicale

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference73 articles.

1. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. 2002. Molecular biology of the cell, 6th ed. Garland Science, New York, NY.

2. Membrane-Protein Interactions in Cell Signaling and Membrane Trafficking

3. Functional rafts in cell membranes

4. Lipid rafts and membrane dynamics

5. Membrane Organization and Lipid Rafts

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