Characteristics of the GlnH and GlnX Signal Transduction Proteins Controlling PknG-Mediated Phosphorylation of OdhI and 2-Oxoglutarate Dehydrogenase Activity in Corynebacterium glutamicum-Reference-Cited by-同舟云学术

Characteristics of the GlnH and GlnX Signal Transduction Proteins Controlling PknG-Mediated Phosphorylation of OdhI and 2-Oxoglutarate Dehydrogenase Activity in Corynebacterium glutamicum

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Sundermeyer Lea¹,Bosco Graziella¹,Gujar Srushti¹²³,Brocker Melanie¹,Baumgart Meike¹^ORCID,Willbold Dieter²³^ORCID,Weiergräber Oliver H.²,Bellinzoni Marco⁴^ORCID,Bott Michael¹⁵^ORCID

Affiliation:

1. IBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum Jülich, Jülich, Germany

2. IBI-7: Structural Biochemistry, Institute of Biological Information Processing, Forschungszentrum Jülich, Jülich, Germany

3. Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

4. Institut Pasteur, Université de Paris Cité, CNRS UMR3528, Unité de Microbiologie Structurale, Paris, France

5. Bioeconomy Science Center (BioSC), Forschungszentrum Jülich, Jülich, Germany

Abstract

Actinobacteria comprise a large number of species playing important roles in biotechnology and medicine, such as Corynebacterium glutamicum , the major industrial amino acid producer, and Mycobacterium tuberculosis , the pathogen causing tuberculosis. Many actinobacteria use a signal transduction process in which the phosphorylation status of OdhI (corynebacteria) or GarA (mycobacteria) regulates the carbon flux at the 2-oxoglutarate node.

Funder

Deutsche Forschungsgemeinschaft

Agence Nationale de la Recherche

Heinrich-Heine-Universität Düsseldorf

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02677-22

Reference72 articles.

1. Handbook of Corynebacterium glutamicum