Duck Enteritis Virus Protein Kinase US3 Inhibits DNA Sensing Signaling by Phosphorylating Interferon Regulatory Factor 7

Author:

Liu Rui1,Gao Li1,Yang Fuchun1,Li Xiaohan1,Liu Changjun1,Qi Xiaole1,Cui Hongyu1,Zhang Yanping1,Wang Suyan1,Wang Xiaomei12ORCID,Gao Yulong1ORCID,Li Kai1ORCID

Affiliation:

1. Division of Avian Immunosuppressive Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

2. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou University, Yangzhou, China

Abstract

Duck enteritis virus (DEV) is a duck alphaherpesvirus that causes an acute and contagious disease with high mortality, resulting in substantial economic losses in the commercial waterfowl industry. The evasion of DNA-sensing pathway-mediated antiviral innate immunity is essential for the persistent infection and replication for many DNA viruses.

Funder

Heilongjiang Natural Science Foundation of China

National Natural Science Foundation of China

Central Public-interest Scientific Institution Basal Research Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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