The Arginine Biosynthesis Pathway of Candida albicans Regulates Its Cross-Kingdom Interaction with Actinomyces viscosus to Promote Root Caries-Reference-Cited by-同舟云学术

The Arginine Biosynthesis Pathway of Candida albicans Regulates Its Cross-Kingdom Interaction with Actinomyces viscosus to Promote Root Caries

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Xiong Kaixin¹,Zhu Hualing¹,Li Yanyao¹,Ji Mengzhen¹,Yan Yujia¹,Chen Xuan¹,Chi Yaqi¹,Yang Xueqin¹,Deng Ling¹,Zhou Xuedong¹,Zou Ling²,Ren Biao¹^ORCID

Affiliation:

1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, China

2. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Conservation Dentistry and Endodontics, West China School of Stomatology, Sichuan University, Chengdu, China

Abstract

Root caries is a critical problem that threatens the oral health of the elderly population. Our results identified the essential roles of the C. albicans arginine biosynthesis pathway in its cross-kingdom interactions with A. viscosus in root caries for the first time and indicated that targeting this pathway was a practical way to treat root caries caused by multiple species.

Funder

National Natural Science Foundation of China

Key Research and Development Projects of Science and Technology Department of Sichuan Province

SPDST | Applied Basic Research Program of Sichuan Province

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00782-22

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