Using a 29-mRNA Host Response Classifier To Detect Bacterial Coinfections and Predict Outcomes in COVID-19 Patients Presenting to the Emergency Department
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Published:2022-12-21
Issue:6
Volume:10
Page:
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ISSN:2165-0497
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Container-title:Microbiology Spectrum
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language:en
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Short-container-title:Microbiol Spectr
Author:
Ram-Mohan Nikhil1ORCID, Rogers Angela J.2, Blish Catherine A.3, Nadeau Kari C.2, Zudock Elizabeth J.1, Kim David1, Quinn James V.1, Sun Lixian4, Liesenfeld Oliver4, Yang Samuel1ORCID, Hashemi Marjan M., Tjandra Kristel C., Newberry Jennifer A., Blomkalns Andra L., O’Hara Ruth, Ashley Euan, Mann Rosen, Visweswaran Anita, Ranganath Thanmayi, Roque Jonasel, Manohar Monali, Din Hena Naz, Kumar Komal, Jee Kathryn, Noon Brigit, Anderson Jill, Fay Bethany, Schreiber Donald, Zhao Nancy, Vergara Rosemary, McKechnie Julia, Wilk Aaron, de la Parte Lauren, Dantzler Kathleen Whittle, Ty Maureen, Kathale Nimish, Rustagi Arjun, Martinez-Colon Giovanny, Ivison Geoff, Pi Ruoxi, Lee Maddie, Brewer Rachel, Hollis Taylor, Baird Andrea, Ugur Michele, Bogusch Drina, Nahass Georgie, Haider Kazim, Tran Kim Quyen Thi, Simpson Laura, Tal Michal, Chang Iris, Do Evan, Fernandes Andrea, Lee Allie, Ahuja Neera, Snow Theo, Krempski James, ,
Affiliation:
1. Department of Emergency Medicine, Stanford University School of Medicine, Stanford, California, USA 2. Department of Medicine—Pulmonary, Allergy & Critical Care Medicine, Stanford University School of Medicine, Stanford, California, USA 3. Department of Medicine/Infectious Diseases, Stanford University School of Medicine, Stanford, California, USA 4. Inflammatix, Inc., Burlingame, California, USA
Abstract
We assay the utility of the single-test IMX-BVN-3/IMX-SEV-3 classifiers that require just 2.5 mL of patient blood in concurrently detecting viral and bacterial infections as well as predicting the severity and 30-day outcome from the infection. A point-of-care device, in development, will circumvent the need for blood culturing and drastically reduce the time needed to detect an infection.
Funder
HHS | NIH | National Institute of Allergy and Infectious Diseases
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology
Cited by
3 articles.
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