A High-Salt Diet Exacerbates Liver Fibrosis through <i>Enterococcus</i> -Dependent Macrophage Activation-Reference-Cited by-同舟云学术

A High-Salt Diet Exacerbates Liver Fibrosis through Enterococcus -Dependent Macrophage Activation

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Zhang Xujun¹²,Liang Yan¹³,Jiang Jingjing¹,Lu Chong⁴,Shi Fan¹,Cao Qingyi¹,Zhang Yanhui⁵,Diao Hongyan¹^ORCID

Affiliation:

1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China

2. Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China

3. Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

4. Department of Gastroenterology, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang, China

5. Jinan Microecological Biomedicine Shandong Laboratory, Jinan, China

Abstract

This study further confirms that Enterococcus induce liver fibrosis in mice. These results indicate that an HSD can exacerbate liver fibrosis by altering the gut microbiota composition, thus impairing intestinal barrier function. Therefore, this may serve as a new target for liver fibrosis therapy and gut microbiota management.

Funder

MOST | National Key Research and Development Program of China

The key Research and Development Plan of Zhejiang Province

Research Project of Jinan Microecological Biomedicine Shangdong Laboratory

MOE | Fundamental Research Funds for the Central Universities

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03403-22

Reference42 articles.