ISG15 Is a Novel Regulator of Lipid Metabolism during <i>Vaccinia Virus</i> Infection-Reference-Cited by-同舟云学术

ISG15 Is a Novel Regulator of Lipid Metabolism during Vaccinia Virus Infection

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Albert Manuel¹^ORCID,Vázquez Jesús²,Falcón-Pérez Juan M.³,Balboa María A.⁴⁵,Liesa Marc⁶⁷,Balsinde Jesús⁴⁵,Guerra Susana¹^ORCID

Affiliation:

1. Department of Preventive Medicine, Public Health and Microbiology, Universidad Autónoma de Madrid, Madrid, Spain

2. Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII), Madrid, Spain

3. CIC-bioGUNE—Centro de Investigación Cooperativa en Biociencias, Vizcaya, Spain

4. Consejo Superior de Investigaciones Científicas (CSIC), Instituto de Biología y Genética Molecular, Valladolid, Spain

5. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain

6. Department of Medicine, Endocrinology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA

7. Institut de Biologia Molecular de Barcelona, IBMB, CSIC, Barcelona, Spain

Abstract

The functions of ISG15 are continuously expanding, and growing evidence supports its role as a relevant modulator of cell metabolism. In this work, we highlight how the absence of ISG15 impacts macrophage lipid metabolism in the context of viral infections and how poxviruses modulate metabolism to ensure successful replication. Our results open the door to new advances in the comprehension of macrophage immunometabolism and the interaction between VACV and the host.

Funder

MEC | Instituto de Salud Carlos III

MEC | Spanish National Plan for Scientific and Technical Research and Innovation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03893-22

Reference116 articles.

1. Interferon-Stimulated Gene 15 and the Protein ISGylation System

2. The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15