COVID-19 Antigen Results Correlate with the Quantity of Replication-Competent SARS-CoV-2 in a Cross-Sectional Study of Ambulatory Adults during the Delta Wave-Reference-Cited by-同舟云学术

COVID-19 Antigen Results Correlate with the Quantity of Replication-Competent SARS-CoV-2 in a Cross-Sectional Study of Ambulatory Adults during the Delta Wave

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Tu Yuan-Po¹^ORCID,Green Christopher²^ORCID,Hao Linhui³,Greninger Alexander L.⁴^ORCID,Morton Jennifer F.⁵^ORCID,Sights Heather A.¹^ORCID,Gale Michael³^ORCID,Drain Paul K.⁵^ORCID

Affiliation:

1. The Everett Clinic – Part of Optum, Everett, Washington, USA

2. Abbott Laboratories, Abbott Park, Illinois, USA

3. Department of Immunology, Center for Innate Immunity and Immune Disease, Center for Emerging & Re-emerging Infectious Diseases, University of Washington, Seattle, Washington, USA

4. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA

5. Department of Global Health and International Clinical Research Center, University of Washington, Seattle, Washington, USA

Abstract

Do rapid antigen test results correlate with replication-competent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (i.e., infectious) virus? In this cross-sectional diagnostic study of 626 adults, the sensitivity of the antigen test to identify replication-competent SARS-CoV-2 was 63.6% in asymptomatic and 91.0% in symptomatic participants. Viral culture titers were the highest at the onset of symptoms and rapidly declined by 7 days after symptom onset.

Funder

Abbott | Abbott Diagnostics

HHS | NIH | OSC | Common Fund

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00064-23

Reference21 articles.

1. Rapid Diagnostic Testing for SARS-CoV-2