Antibacterial Activity of an FtsZ Inhibitor Celastrol and Its Synergistic Effect with Vancomycin against Enterococci In Vitro and In Vivo

Author:

Lu Xi1,Wang Yanxiang1,Guo Wei1,Zhang Zhimeng1,Hu Xinxin1,Nie Tongying1,Yang Xinyi1,Li Congran1,Wang Xiukun1,Li Xue1,Lu Yun1,Li Guoqing1,Zhang Youwen1ORCID,Sun Lang1ORCID,Pang Jing1ORCID,You Xuefu1

Affiliation:

1. Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

Abstract

The emergence and transmission of VRE pose a significant medical and public health challenge. CEL, well-known for a wide range of biological activities, has not previously been investigated for its synergistic effect with vancomycin against VRE.

Funder

CAMS Initiative for Innovative Medicine

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference22 articles.

1. Agudelo HN, Huycke MM. 2014. Enterococcal Disease, Epidemiology, and Implications for Treatment. In Gilmore MS, Clewell DB, Ike Y, Shankar N (ed), Enterococci: from commensals to leading causes of drug resistant infection, Boston.

2. Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus

3. A New Era for TreatingEnterococcus faecalisEndocarditis

4. Health care-associated infections – an overview

5. World Health Organization. 2017. WHO publishes list of bacteria for which new antibiotics are urgently needed. https://www.who.int/news/item/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed.

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