A Mycobacterium tuberculosis Effector Targets Mitochondrion, Controls Energy Metabolism, and Limits Cytochrome <i>c</i> Exit-Reference-Cited by-同舟云学术

A Mycobacterium tuberculosis Effector Targets Mitochondrion, Controls Energy Metabolism, and Limits Cytochrome c Exit

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Martin Marianne¹,deVisch Angelique²,Boudehen Yves-Marie³,Barthe Philippe²,Gutierrez Claude³,Turapov Obolbek⁴,Aydogan Talip¹,Heriaud Laurène²,Gracy Jerome²,Neyrolles Olivier³^ORCID,Mukamolova Galina V.⁴^ORCID,Letourneur François¹^ORCID,Cohen-Gonsaud Martin²^ORCID

Affiliation:

1. Laboratory of Pathogen Host Interactions, Université de Montpellier, CNRS, INSERM, Montpellier, France

2. Centre de Biochimie Structurale, CNRS, INSERM, Université de Montpellier, Montpellier, France

3. Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse CNRS, UPS, Toulouse, France

4. Leicester Tuberculosis Research Group, Department of Respiratory Sciences, University of Leicester, Leicester, UK

Abstract

In this article, using a combination of techniques (bioinformatics, structural biology, and cell biology), we identified and characterized a new class of effectors present only in intracellular mycobacteria. These proteins specifically target host cell mitochondria when ectopically expressed in cells.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01066-23

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