Neutralizing Antibody Response of the Wild-Type/Omicron BA.1 Bivalent Vaccine as the Second Booster Dose against Omicron BA.2 and BA.5-Reference-Cited by-同舟云学术

Neutralizing Antibody Response of the Wild-Type/Omicron BA.1 Bivalent Vaccine as the Second Booster Dose against Omicron BA.2 and BA.5

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Kawasuji Hitoshi¹,Morinaga Yoshitomo²³^ORCID,Tani Hideki²⁴^ORCID,Saga Yumiko²⁴,Yamada Hiroshi²,Yoshida Yoshihiro¹,Takegoshi Yusuke¹,Kaneda Makito¹,Murai Yushi¹,Kimoto Kou¹,Ueno Akitoshi¹,Miyajima Yuki¹,Nagaoka Kentaro¹,Ono Chikako⁵⁶,Matsuura Yoshiharu⁵⁶,Niimi Hideki³⁷,Yamamoto Yoshihiro¹³

Affiliation:

1. Department of Clinical Infectious Diseases, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan

2. Department of Microbiology, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan

3. Clinical and Research Center for Infectious Diseases, Toyama University Hospital, Toyama, Japan

4. Department of Virology, Toyama Institute of Health, Toyama, Japan

5. Laboratory of Virus Control, Center for Infectious Disease Education and Research (CiDER), Osaka University, Osaka, Japan

6. Laboratory of Virus Control, Research Institute for Microbial Diseases (RIMD), Osaka University, Osaka, Japan

7. Department of Clinical Laboratory and Molecular Pathology, Toyama University Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan

Abstract

Although Omicron BA.1-containing bivalent vaccines have been authorized, real-world data validating their safety and antibody responses remain scarce. We conducted a prospective longitudinal study to assess the safety, immunogenicity, and reactogenicity of the second booster dose with the Omicron BA.1 bivalent vaccine in health care workers.

Funder

Toyama Pharmaceutical Valley Development Consortium

Morinomiyako Medical Research Roundation

Hokuriku Bank grant-in-aid for Young Scientists

Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Kurozumi Medical Foundation

University of Toyama

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology