In Vitro Antibacterial Activity of Silver Nanoparticles Conjugated with Amikacin and Combined with Hyperthermia against Drug-Resistant and Biofilm-Producing Strains

Author:

Palau Marta123ORCID,Muñoz Estela1ORCID,Gusta Muriel F.456,Larrosa Nieves237,Gomis Xavier13,Gilabert Joan8,Almirante Benito123,Puntes Victor4569,Texidó Robert10,Gavaldà Joan123ORCID

Affiliation:

1. Antibiotic Resistance Laboratory, Vall d’Hebron Research Institute (VHIR), Infectious Diseases Department, Vall d’Hebron University Hospital, Barcelona, Spain

2. Spanish Network for Research in Infectious Diseases (REIPI RD19/0016), Instituto de Salud Carlos III, Madrid, Spain

3. CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain

4. Institut Català de Nanociència i Nanotecnologia (ICN2), CSIC, The Barcelona Institute of Science and Technology (BIST), Campus UAB, Bellaterra, Barcelona, Spain

5. Vall d’Hebron University Hospital, Barcelona, Spain

6. CIBER en Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Madrid, Spain

7. Microbiology Department, Vall d’Hebron University Hospital, Barcelona, Spain

8. Tractivus SL, Barcelona, Spain

9. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

10. Grup d’Enginyeria de Materials (GEMAT), Universitat Ramón Llull, Barcelona, Spain

Abstract

Antimicrobial resistance (AMR) is one of the greatest public health challenges, accounting for 1.27 million deaths worldwide in 2019. Biofilms, a complex microbial community, directly contribute to increased AMR.

Funder

Spanish Network for the Research in Infectious Disease

Fundació la Marató de TV3

MEC | Instituto de Salud Carlos III

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference55 articles.

1. CDC. 2019. Antibiotic resistance threats in the United States, 2019. US Department of Health and Human Services, CDC, Atlanta, GA.

2. The antibiotic resistance crisis. Part 1: causes and threats;Ventola CL;P T,2015

3. Antibiotic resistance—the need for global solutions

4. Access to effective antimicrobials: a worldwide challenge

5. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

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