Pseudomonas aeruginosa Induces Interferon-β Production to Promote Intracellular Survival-Reference-Cited by-同舟云学术

Pseudomonas aeruginosa Induces Interferon-β Production to Promote Intracellular Survival

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Yang Ling¹²,Zhang Yu-Wei¹²,Liu Yang¹²,Xie Ying-Zhou²,Weng Dong²,Ge Bao-Xue³,Liu Hai-Peng³,Xu Jin-Fu¹²^ORCID

Affiliation:

1. Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China

2. Institute of Respiratory Medicine, School of Medicine, Tongji University, Shanghai, China

3. Clinical Translation Research Center, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China

Abstract

The link between innate immunity and intracellular Pseudomonas aeruginosa is unclear. Our studies illuminated the role of interferon-β (IFN-β) in remote intracellular PA infection. Furthermore, our experimental evidence also indicated that IL-1β is a negative regulator of IFN-β production and, in particular, P. aeruginosa infection. The inhibition of IFN-β may be used as a potential therapeutic method against pulmonary PA infection.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01550-22

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