Proteomic Response Revealed Signaling Pathways Involving in the Mechanism of Polymyxin B-Induced Melanogenesis-Reference-Cited by-同舟云学术

Proteomic Response Revealed Signaling Pathways Involving in the Mechanism of Polymyxin B-Induced Melanogenesis

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Zhang Chuhan¹²³^ORCID,Liu Xiaofen¹²³^ORCID,Wu Hailan¹²³,Wang Yu¹²³,Fan Yaxin¹²³,Guo Beining¹²³,Bian Xingchen¹²³,Li Xin¹²³,Zhang Jing¹²³⁴^ORCID

Affiliation:

1. Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China

2. Key Laboratory of Clinical Pharmacology of Antibiotics, National Health Commission of the People’s Republic of China, Shanghai, China

3. National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China

4. Phase I Clinical Trial Center, Huashan Hospital, Fudan University, Shanghai, China

Abstract

Polymyxin B-induced skin hyperpigmentation seriously affects the psychological health and compliance of patients. This study provides a proteomic clue to the mechanism at the cellular level for understanding polymyxin B-induced hyperpigmentation, contributing to a follow-up investigation of the corresponding PI3K/Akt signaling transduction pathway and calcium signaling pathway.

Funder

Science and Technology Commission of Shanghai Municipality

Shanghai Municipal Human Resources and Social Security Bureau

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02730-21

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