Emergence of Extensively Drug-Resistant ST170 Citrobacter portucalensis with Plasmids pK218-KPC, pK218-NDM, and pK218-SHV from a Tertiary Hospital, China

Abstract

This is the first report of extensively drug-resistant C. portucalensis harboring both bla KPC-2 and bla NDM-1 . This study will not only extend the understanding of the structural dissection of plasmids and chromosomes carried in C. portucalensis , but also expand knowledge of the genetic environment of the bla KPC-2 and bla NDM-1 genes. bla KPC-2 and bla NDM-1 genes have been suggested to facilitate the propagation and persistence of their host bacteria under different antimicrobial selection pressures.