Contribution of Surface-Exposed Loops on the HPV16 Capsid to Antigenic Domains Recognized by Vaccine or Natural Infection Induced Neutralizing Antibodies-Reference-Cited by-同舟云学术

Contribution of Surface-Exposed Loops on the HPV16 Capsid to Antigenic Domains Recognized by Vaccine or Natural Infection Induced Neutralizing Antibodies

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Godi Anna¹,Vaghadia Stuti¹,Cocuzza Clementina²,Miller Elizabeth³,Beddows Simon¹⁴^ORCID

Affiliation:

1. Reference Services Division, UK Health Security Agency (UKHSA), London, United Kingdom

2. Department of Surgery and Translational Medicine, University of Milan-Bicocca, Monza, Italy

3. Immunisation and Vaccine-Preventable Diseases Division, UKHSA, London, United Kingdom

4. Blood Safety, Hepatitis, Sexually Transmitted Infections and HIV Division, UKHSA, London, United Kingdom

Abstract

The human papillomavirus type 16 (HPV16) major virus coat (capsid) protein is a target for antibodies induced by both natural infection and vaccination. Vaccine-induced immunity is highly protective against HPV16-related infection and disease while natural infection associated immunity significantly less so.

Funder

National Institute for Health Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00779-22

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