A Randomized Clinical Trial Testing Hydroxychloroquine for Reduction of SARS-CoV-2 Viral Shedding and Hospitalization in Early Outpatient COVID-19 Infection-Reference-Cited by-同舟云学术

A Randomized Clinical Trial Testing Hydroxychloroquine for Reduction of SARS-CoV-2 Viral Shedding and Hospitalization in Early Outpatient COVID-19 Infection

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Spivak Adam M.¹^ORCID,Barney Bradley J.²,Greene Tom¹³,Holubkov Richard²,Olsen Cody S.²,Bridges Jordan²,Srivastava Raj⁴,Webb Brandon⁵^ORCID,Sebahar Frances²,Huffman Ainsley⁶,Pacchia Christina F.²,Dean J. Michael²,Hess Rachel¹³

Affiliation:

1. Department of Medicine, University of Utah, Salt Lake City, Utah, USA

2. Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA

3. Department of Population Health Sciences, University of Utah, Salt Lake City, Utah, USA

4. Senior Medical Executive Director, Intermountain Healthcare Delivery Institute, Intermountain Healthcare, Salt Lake City, Utah, USA

5. Division of Infectious Diseases, Intermountain Healthcare, Salt Lake City, Utah, USA

6. Utah Clinical and Translational Science Institute, University of Utah, Salt Lake City, Utah, USA

Abstract

Early in the COVID-19 pandemic, no effective treatment existed to prevent clinical worsening of COVID-19 among recently diagnosed outpatients. Hydroxychloroquine received attention as a possible early treatment; however, quality prospective studies were lacking. We conducted a clinical trial to test the ability of hydroxychloroquine to prevent clinical worsening of COVID-19.

Funder

HHS | NIH | National Center for Advancing Translational Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04674-22

Reference28 articles.

1. A pneumonia outbreak associated with a new coronavirus of probable bat origin

2. A Novel Coronavirus from Patients with Pneumonia in China, 2019

3. Seroprevalence of Antibodies to SARS-CoV-2 in 10 Sites in the United States, March 23-May 12, 2020

4. The Early Natural History of SARS-CoV-2 Infection

5. An Early Test-and-Treat Strategy for Severe Acute Respiratory Syndrome Coronavirus 2

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