High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens

Author:

Counoupas Claudio12,Pino Paco3,Stella Alberto O.4,Ashley Caroline1,Lukeman Hannah1,Bhattacharyya Nayan D.1,Tada Takuya5,Anchisi Stephanie3,Metayer Charles3,Martinis Jacopo3,Aggarwal Anupriya4,Dcosta Belinda M.5,Britton Warwick J.2,Kint Joeri3,Wurm Maria J.3,Landau Nathaniel R.5ORCID,Steain Megan1ORCID,Turville Stuart G.4,Wurm Florian M.36,David Sunil A.7,Triccas James A.18ORCID

Affiliation:

1. School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia

2. Tuberculosis Research Program, Centenary Institute, Sydney, New South Wales, Australia

3. ExcellGene SA, Monthey, Switzerland

4. Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia

5. Department of Microbiology, NYU Grossman School of Medicine, New York, New York, USA

6. Life Science Faculty, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland

7. Virovax, Lawrence, Kansas, USA

8. Sydney Institute for Infectious Diseases and the Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, Australia

Abstract

There is an urgent need for next-generation COVID-19 vaccines that are safe, demonstrate high protective efficacy against SARS-CoV-2 variants and can be manufactured at scale. We describe a vaccine candidate (CoVac-II) that is based on stabilized, trimeric spike antigen produced in an optimized, scalable and chemically defined production process.

Funder

Medical Research Future Fund Australia

HHS | National Institutes of Health

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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