Growth Transformation of B Cells by Epstein-Barr Virus Requires <i>IMPDH2</i> Induction and Nucleolar Hypertrophy-Reference-Cited by-同舟云学术

Growth Transformation of B Cells by Epstein-Barr Virus Requires IMPDH2 Induction and Nucleolar Hypertrophy

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Sugimoto Atsuko¹²³,Watanabe Takahiro³^ORCID,Matsuoka Kazuhiro²,Okuno Yusuke⁴,Yanagi Yusuke³,Narita Yohei⁵,Mabuchi Seiyo³⁶,Nobusue Hiroyuki⁷,Sugihara Eiji⁷⁸,Hirayama Masaya⁹¹⁰,Ide Tomihiko¹⁸,Onouchi Takanori⁸,Sato Yoshitaka³^ORCID,Kanda Teru¹¹,Saya Hideyuki⁷,Iwatani Yasumasa²^ORCID,Kimura Hiroshi³^ORCID,Murata Takayuki¹³^ORCID

Affiliation:

1. Department of Virology, Fujita Health University School of Medicine, Toyoake, Japan

2. Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan

3. Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan

4. Department of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

5. Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA

6. Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan

7. Division of Gene Regulation, Cancer Center, Research Promotion Headquarters, Fujita Health University, Toyoake, Japan

8. Open Facility Center, Research Promotion Headquarters, Fujita Health University, Toyoake, Japan

9. Department of Morphology and Diagnostic Pathology, School of Medical Sciences, Fujita Health University, Toyoake, Japan

10. Department of Biomedical Molecular Sciences, Graduate School of Medicine, Fujita Health University, Toyoake, Japan

11. Department of Microbiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan

Abstract

EBV infections cause nucleolar enlargement via the induction of IMPDH2, which are essential for B cell growth transformation by EBV. Although the significance of IMPDH2 induction and nuclear hypertrophy in the tumorigenesis of glioblastoma has been reported, EBV infection brings about the change quickly by using its transcriptional cofactor, EBNA2, and MYC. Moreover, we present here, for the novel, basic evidence that an IMPDH2 inhibitor, namely, MPA or MMF, can be used for EBV-positive posttransplant lymphoproliferative disorder (PTLD).

Funder

Nihon Shinyaku

Chemo-Sero Therapeutic Research Institute

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

Takeda Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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