iTRAQ-Based Quantitative Proteomic Analysis of Acinetobacter baumannii under Hypoxia and Normoxia Reveals the Role of OmpW as a Virulence Factor

Author:

Gil-Marqués María Luisa12,Pachón Jerónimo23,Smani Younes1245ORCID

Affiliation:

1. Unit of Infectious Diseases, Microbiology and Preventive Medicine, Virgen del Rocío University Hospital, Seville, Spain

2. Institute of Biomedicine of Seville, IBiS, University Hospital Virgen del Rocío/CSIC/University of Seville, Sevilla, Spain

3. Department of Medicine, University of Seville, Sevilla, Spain

4. CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain

5. Department of Molecular Biology and Biochemical Engineering, Andalusian Center of Developmental Biology, CSIC, University of Pablo de Olavide, Seville, Spain

Abstract

Acinetobacter baumannii causes infections that are very difficult to treat due to the high rate of resistance to most and sometimes all of the antimicrobials used in the clinical setting. There is an important need to develop new strategies to combat A. baumannii infections.

Funder

MEC | Instituto de Salud Carlos III

Ministerio de Educacion, Cultura y Deporte

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference48 articles.

1. Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

2. Acinetobacter baumannii: biology and drug resistance — role of carbapenemases

3. European Centre for Disease Prevention and Control. 2015. Annual epidemiological report 2014: antimicrobial resistance and healthcare associated infections. European Centre for Disease Prevention and Control, Stockholm, Sweden. https://www.ecdc.europa.eu/sites/default/files/documents/antimicrobial-resistance-annual-epidemiological-report.pdf.

4. Acinetobacter baumannii: human infections, factors contributing to pathogenesis and animal models

5. Bacterial Adaptation during Chronic Respiratory Infections

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