Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome-Reference-Cited by-同舟云学术

Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Ashby Ethan C.¹,Havens Jennifer L.¹^ORCID,Rollosson Lindsey M.¹,Hardin Johanna²,Schulz Danae¹^ORCID

Affiliation:

1. Department of Biology, Harvey Mudd College, Claremont, California, USA

2. Department of Mathematics and Statistics, Pomona College, Claremont, California, USA

Abstract

The disease African trypanosomiasis imposes a severe human and economic burden for communities in sub-Saharan Africa. The parasite that causes the disease is transmitted to the bloodstream of a human or ungulate via the tsetse fly.

Funder

National Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00147-23

Reference80 articles.

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4. Spliced Leader Trapping Reveals Widespread Alternative Splicing Patterns in the Highly Dynamic Transcriptome of Trypanosoma brucei

5. Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons

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