Insights into the Unique Lung Microbiota Profile of Pulmonary Tuberculosis Patients Using Metagenomic Next-Generation Sequencing-Reference-Cited by-同舟云学术

Insights into the Unique Lung Microbiota Profile of Pulmonary Tuberculosis Patients Using Metagenomic Next-Generation Sequencing

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Xiao Guohui¹²^ORCID,Cai Zhao³,Guo Qinglong¹,Ye Taosheng¹,Tang Yimin¹,Guan Peikun⁴,Zhang Juanjuan¹,Ou Min¹,Fu Xiangdong¹,Ren Lili⁵,Yu Minfei⁴,Wang Zhaoqin¹,Liu Lei¹,Yang Liang³,Zhang Guoliang¹²

Affiliation:

1. National Clinical Research Center for Infectious Diseases, Shenzhen Third People’s Hospital, Southern University of Science and Technology, Shenzhen, China

2. Guangdong Key Laboratory of Regional Immunity and Diseases, Shenzhen University School of Medicine, Shenzhen, China

3. School of Medicine, Southern University of Science and Technology, Shenzhen, China

4. Guangzhou Sagene Biotech Co., Ltd., Guangzhou, China

5. Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Abstract

Characterization of the lung microbiota could lead to a better understanding of the pathogenesis of pulmonary TB. Here, we applied the metagenomic shotgun sequencing instead of 16S rRNA sequencing method to characterize the lung microbiota using the BALF samples instead of sputum.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01901-21

Reference61 articles.

1. Lifetime Risks, Incubation Period, and Serial Interval of Tuberculosis

2. Updates in the Treatment of Active and Latent Tuberculosis

3. Adverse drug reactions in tuberculosis and management