Protein Interactome Analysis of the Type IX Secretion System Identifies PorW as the Missing Link between the PorK/N Ring Complex and the Sov Translocon-Reference-Cited by-同舟云学术

Protein Interactome Analysis of the Type IX Secretion System Identifies PorW as the Missing Link between the PorK/N Ring Complex and the Sov Translocon

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Gorasia Dhana G.¹,Lunar Silva Ignacio²,Butler Catherine A.¹,Chabalier Maïalène²,Doan Thierry²,Cascales Eric²^ORCID,Veith Paul D.¹,Reynolds Eric C.¹^ORCID

Affiliation:

1. Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, Victoria, Australia

2. Laboratoire d’Ingénierie des Systémes Macromoléculaires (LISM - UMR7255), Institut de Microbiologie, Bioénergies et Biotechnologie (IM2B), CNRS - Aix-Marseille Universite, Marseille, France

Abstract

The T9SS is a newly identified protein secretion system of the Fibrobacteres - Chlorobi - Bacteroidetes superphylum used by pathogens associated with diseases of humans, fish, and poultry for the secretion and cell surface attachment of virulence factors. The T9SS comprises three known modules: (i) the trans-envelope core module comprising the PorL/M motor and the PorK/N ring, (ii) the outer membrane Sov translocon, and (iii) the cell surface attachment complex.

Funder

Department of Health | National Health and Medical Research Council

Australian Research Council

Centre National de la Recherche Scientifique

Agence Nationale de la Recherche

Excellence initiative of Aix-Marseille Universite

Investissements d'Avenir

ANR

Australian Dental Research Foundation

Publisher

American Society for Microbiology

Subject