Clarithromycin Inhibits Pneumolysin Production via Downregulation of ply Gene Transcription despite Autolysis Activation-Reference-Cited by-同舟云学术

Clarithromycin Inhibits Pneumolysin Production via Downregulation of ply Gene Transcription despite Autolysis Activation

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Domon Hisanori¹²^ORCID,Isono Toshihito¹,Hiyoshi Takumi¹²³,Tamura Hikaru¹³,Sasagawa Karin¹³,Maekawa Tomoki¹²³,Hirayama Satoru¹,Yanagihara Katsunori⁴,Terao Yutaka¹²

Affiliation:

1. Division of Microbiology and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

2. Center for Advanced Oral Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

3. Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

4. Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Abstract

Pneumolysin is a potent intracellular toxin possessing multiple functions that augment pneumococcal virulence. For over 10 years, sub-MICs of macrolides, including clarithromycin, have been recognized to decrease pneumolysin production and release from pneumococcal cells.

Funder

MEXT | Japan Society for the Promotion of Science

Takeda Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00318-21

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2. Attributable healthcare utilization and cost of pneumoniae due to drug-resistant Streptococcus pneumoniae: a cost analysis