TP0586532, a Novel Non-Hydroxamate LpxC Inhibitor: Potentiating Effect on <i>In Vitro</i> Activity of Meropenem against Carbapenem-Resistant Enterobacteriaceae-Reference-Cited by-同舟云学术

TP0586532, a Novel Non-Hydroxamate LpxC Inhibitor: Potentiating Effect on In Vitro Activity of Meropenem against Carbapenem-Resistant Enterobacteriaceae

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Yoshida Ippei¹,Takata Iichiro¹,Fujita Kiyoko¹,Takashima Hajime²,Sugiyama Hiroyuki¹³^ORCID

Affiliation:

1. Pharmacology Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama, Japan

2. Chemistry Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama, Japan

3. Medical Information, Taisho Pharmaceutical Co., Ltd., Tokyo, Japan

Abstract

Carbapenem-resistant Enterobacteriaceae (CRE) are an urgent public health threat, as therapeutic options are limited. TP0586532 is a novel LpxC inhibitor that inhibits the synthesis of lipopolysaccharides in the outer membranes of Gram-negative bacteria.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00828-22

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