Carbonic Anhydrase Inhibition as a Target for Antibiotic Synergy in Enterococci-Reference-Cited by-同舟云学术

Carbonic Anhydrase Inhibition as a Target for Antibiotic Synergy in Enterococci

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Chilambi Gayatri Shankar¹,Wang Yu-Hao¹,Wallace Nathan R.¹,Obiwuma Chetachukwu¹,Evans Kirsten M.¹,Li Yanhong¹²,Shalaby Menna-Allah W.³,Flaherty Daniel P.³,Shields Ryan K.¹^ORCID,Doi Yohei¹^ORCID,Van Tyne Daria¹^ORCID

Affiliation:

1. Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

2. Tsinghua University School of Medicine, Beijing, China

3. Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, USA

Abstract

Enterococcal infections can be difficult to treat, and new therapeutic approaches are needed. In studying an E. faecalis clinical strain from an infected patient, we found that the bacteria were rendered hypersusceptible to aminoglycoside antibiotics through a mutation that disrupted the α-CA.

Funder

University of Pittsburgh Department of Medicine

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03963-22

Reference45 articles.

1. Friend Turned Foe: Evolution of Enterococcal Virulence and Antibiotic Resistance

2. A New Era for TreatingEnterococcus faecalisEndocarditis