O -Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli -Containing Vacuoles in Macrophage-Like Cells-Reference-Cited by-同舟云学术

O -Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli -Containing Vacuoles in Macrophage-Like Cells

Published:2021-12-22 Issue:3 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Yang Jinghua¹²^ORCID,Ma Wei¹²,Wu Yuanyuan³,Zhou Hui¹,Song Siyu³,Cao Yuqi⁴,Wang Chengxu⁵,Liu Xiangyuan⁴,Ren Jinwei¹,Duan Jinyou³,Pei Zhichao³,Jin Cheng¹²^ORCID

Affiliation:

1. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

2. University of Chinese Academy of Sciences, Beijing, China

3. Shanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yanglin, Shanxi, China

4. School of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia, China

5. Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China

Abstract

Escherichia coli K1 is a leading cause of neonatal meningitis. The mortality and morbidity of this disease remain significantly high despite antibiotic therapy.

Funder

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00399-21

Reference61 articles.

1. Bacterial meningitis in the newborn: A prospective study of mortality and morbidity

2. Bacterial meningitis in children