Activity of Omadacycline Alone and in Combination against Carbapenem-Nonsusceptible Acinetobacter baumannii with Varying Minocycline Susceptibility

Author:

Abbey Taylor1,Vialichka Alesia1,Jurkovic Michele1,Biagi Mark2,Wenzler Eric1ORCID

Affiliation:

1. College of Pharmacy, University of Illinois Chicago, Chicago, Illinois, USA

2. College of Pharmacy, University of Illinois Chicago, Rockford, Illinois, USA

Abstract

Treatment of infections due to Acinetobacter baumannii often involves the use of multiple antibiotics simultaneously as combination therapy, but it is unknown which antibiotics are best used together. Tetracycline agents such as minocycline and tigecycline maintain good activity against A. baumannii and are often used with one or more other agents to achieve better killing of the bacteria.

Funder

Paratek Pharmaceuticals

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference61 articles.

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2. U.S. Department of Health and Human Services Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States 2019. 2019. https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf. Accessed November 14 2021.

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5. CLSI. 2021. Performance standards for antimicrobial susceptibility testing, M100-S31 ed. Clinical and Laboratory Standards Insitute, Wayne, PA.

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