Homologous Sequential Immunization Using Salmonella Oral Administration Followed by an Intranasal Boost with Ferritin-Based Nanoparticles Enhanced the Humoral Immune Response against H1N1 Influenza Virus

Author:

Wang Zhannan1,Zhang Tongyu1,Jia Futing1,Ge Chongbo1,He Yingkai1,Tian Yawen1,Wang Wenfeng1,Yang Guilian1,Huang Haibin1,Wang Jianzhong1,Shi Chunwei1,Yang Wentao1,Cao Xin1,Zeng Yan1,Wang Nan1,Qian Aidong1,Wang Chunfeng1,Jiang Yanlong1ORCID

Affiliation:

1. College of Animal Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University, Changchun, China

Abstract

Salmonella -delivered in situ nanoparticle platforms may provide novel nanoparticle vaccines for oral administration, which would be beneficial for veterinary applications. The combination of administering Salmonella -vectored, self-assembled nanoparticles and an intranasal boost with purified nanoparticles significantly increased the production of effector memory T cells and lung resident memory T cells, thereby providing partial protection against an influenza virus challenge.

Funder

MOST | National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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