Inactivation of the Response Regulator AgrA Has a Pleiotropic Effect on Biofilm Formation, Pathogenesis and Stress Response in Staphylococcus lugdunensis-Reference-Cited by-同舟云学术

Inactivation of the Response Regulator AgrA Has a Pleiotropic Effect on Biofilm Formation, Pathogenesis and Stress Response in Staphylococcus lugdunensis

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Aubourg Marion¹,Pottier Marine¹²,Léon Albertine¹²,Bernay Benoit³,Dhalluin Anne¹,Cacaci Margherita⁴,Torelli Riccardo⁴,Ledormand Pierre⁵,Martini Cecilia⁴,Sanguinetti Maurizio⁴,Auzou Michel⁶,Gravey François¹^ORCID,Giard Jean-Christophe¹^ORCID

Affiliation:

1. Université de Caen Normandie, Dynamicure, INSERM U1311, CHU de Caen, Caen, France

2. LABÉO Frank Duncombe, Caen, France

3. Plateforme Proteogen SFR ICORE 4206, Université de Caen Normandie, Caen, France

4. Institute of Microbiology, Catholic University of Sacred Heart, L. go F. Vito 1, Rome, Italy

5. Université de Caen Normandie, ABTE, Caen, France

6. CHU de Caen, Laboratoire de Microbiologie, Caen, France

Abstract

Although belonging to the natural human skin flora, Staphylococcus lugdunensis is recognized as a particularly aggressive and destructive pathogen. This study aimed to characterize the role of the response regulator AgrA, which is a component of the quorum-sensing agr system and known to be a major element in the regulation of pathogenicity and biofilm formation in Staphylococcus aureus .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01598-21

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