Contribution of the Oral and Gastrointestinal Microbiomes to Bloodstream Infections in Leukemia Patients-Reference-Cited by-同舟云学术

Contribution of the Oral and Gastrointestinal Microbiomes to Bloodstream Infections in Leukemia Patients

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

McMahon Stephanie¹,Sahasrabhojane Pranoti²,Kim Jiwoong³,Franklin Samantha¹,Chang Chia-Chi⁴,Jenq Robert R.⁴,Hillhouse Andrew E.⁵⁶,Shelburne Samuel A.²⁴^ORCID,Galloway-Peña Jessica¹⁴⁵^ORCID

Affiliation:

1. Interdisciplinary Genetics Program, Texas A&M University, College Station, Texas, USA

2. Department of Infectious Diseases, Infection Control, and Employee Health, MD Anderson Cancer Center, Houston, Texas, USA

3. Department of Bioinformatics and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA

4. Department of Genomic Medicine, MD Anderson Cancer Center, Houston, Texas, USA

5. Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, USA

6. Texas A&M Institute for Genome Sciences & Society, Texas A&M University, College Station, Texas, USA

Abstract

A major cause of mortality in hematologic malignancy patients is BSI. Previous studies have demonstrated that bacterial translocation from the GI microbiome is a major source of BSIs and is often preceded by increased levels of the infectious taxa in the GI (>30% abundance by 16S rRNA sequencing).

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Cancer Institute

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00415-23

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