Multiple Routes of Antibody-Dependent Enhancement of SARS-CoV-2 Infection-Reference-Cited by-同舟云学术

Multiple Routes of Antibody-Dependent Enhancement of SARS-CoV-2 Infection

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Okuya Kosuke¹^ORCID,Hattori Takanari¹,Saito Takeshi¹,Takadate Yoshihiro¹,Sasaki Michihito²^ORCID,Furuyama Wakako³,Marzi Andrea³^ORCID,Ohiro Yoichi⁴,Konno Satoshi⁵,Hattori Takeshi⁶,Takada Ayato¹⁷^ORCID

Affiliation:

1. Division of Global Epidemiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan

2. Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan

3. Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA

4. Department of Oral and Maxillofacial Surgery, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan

5. Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

6. Department of Respiratory Medicine, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan

7. International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan

Abstract

Potential risks of antibody-dependent enhancement (ADE) in the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been discussed and the proposed mechanism mostly depends on the Fc gamma receptor (FcγR). However, since FcγRs are exclusively expressed on immune cells, which are not primary targets of SARS-CoV-2, the clinical importance of ADE of SARS-CoV-2 infection remains controversial.

Funder

MEXT | Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01553-21

Reference61 articles.

1. Coronavirus Spike Protein and Tropism Changes