BRET-Based Self-Cleaving Biosensors for SARS-CoV-2 3CLpro Inhibitor Discovery-Reference-Cited by-同舟云学术

BRET-Based Self-Cleaving Biosensors for SARS-CoV-2 3CLpro Inhibitor Discovery

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Hou Ningke¹^ORCID,Peng Chen¹,Zhang Lijing¹,Zhu Yuyao¹,Hu Qi¹^ORCID

Affiliation:

1. Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine; and Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China

Abstract

The virus proteases 3CLpro are validated drug targets for developing antivirals to treat coronavirus diseases, such as COVID-19. However, the development of 3CLpro inhibitors relies heavily on BSL-3 laboratories.

Funder

Westlake Education Foundation

Tencent

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02559-21

Reference28 articles.

1. A pneumonia outbreak associated with a new coronavirus of probable bat origin

2. Accelerated Preclinical Paths to Support Rapid Development of COVID-19 Therapeutics