Impact of Pneumococcal and Viral Pneumonia on the Respiratory and Intestinal Tract Microbiomes of Mice

Author:

Gierse Laurin Christopher1,Meene Alexander1,Skorka Sebastian2,Cuypers Fabian2,Surabhi Surabhi2,Ferrero-Bordera Borja1,Kreikemeyer Bernd3ORCID,Becher Dörte1,Hammerschmidt Sven2ORCID,Siemens Nikolai2,Urich Tim1ORCID,Riedel Katharina1ORCID

Affiliation:

1. Institute of Microbiology, University of Greifswald, Greifswald, Germany

2. Department of Molecular Genetics and Infection Biology, Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

3. Institute for Medical Microbiology, Virology and Hygiene, Rostock University Medical Centre, Rostock, Germany

Abstract

Pneumonia is one of the leading causes of death worldwide. Here, we compared the impact of bacterial- and viral-induced pneumonia on the respiratory and gastrointestinal microbiome. Using a meta-omics approach, we identified specific profiles that allow discrimination between bacterial and viral causative.

Funder

EC | EU Social | European Social Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference99 articles.

1. World Health Organization. 2020. WHO report—the top 10 causes of death. www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death. Accessed 3 May 3 2021.

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3. Community-acquired pneumonia

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