Comprehensive Interactome Analysis for the Sole Adenylyl Cyclase Cyr1 of Candida albicans-Reference-Cited by-同舟云学术

Comprehensive Interactome Analysis for the Sole Adenylyl Cyclase Cyr1 of Candida albicans

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Zeng Guisheng¹^ORCID,Neo Suat Peng²,Pang Li Mei¹^ORCID,Gao Jiaxin¹,Chong Shu Chen¹^ORCID,Gunaratne Jayantha²³,Wang Yue¹⁴^ORCID

Affiliation:

1. Infectious Diseases Labs, Singapore

2. Quantitative Proteomics Group, Institute of Molecular and Cell Biology, Singapore

3. Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

4. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Abstract

A critical virulence trait of the human fungal pathogen Candida albicans is its ability to undergo the yeast-to-hypha transition in response to diverse environmental and cellular stimuli. Previous studies suggested that the sole adenylyl cyclase of C. albicans , Cyr1, is a multivalent signal sensor and integrator synthesizing cAMP to activate the downstream hypha-promoting events through the cAMP/protein kinase A pathway.

Funder

A*STAR | Biomedical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03934-22

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