WhiB4 Is Required for the Reactivation of Persistent Infection of Mycobacterium marinum in Zebrafish-Reference-Cited by-同舟云学术

WhiB4 Is Required for the Reactivation of Persistent Infection of Mycobacterium marinum in Zebrafish

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Lin Chen¹,Tang Yuting¹,Wang Yuchen²,Zhang Junli¹,Li Yeyu¹,Xu Shuqin¹,Xia Bin³,Zhai Qiran³,Li Yao¹,Zhang Lu²⁴^ORCID,Liu Jun⁵

Affiliation:

1. State Key Laboratory of Genetic Engineering, School of Life Science, Institute of Genetics, Fudan University, Shanghai, China

2. Department of Microbiology, School of Life Science, Fudan University, Shanghai, China

3. Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, School of Life Sciences, Peking University, Beijing, China

4. Shanghai Engineering Research Center of Industrial Microorganisms, Shanghai, China

5. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

Abstract

About one-quarter of the world’s population has latent TB infection, and 5 to 10% of those individuals will fall ill with TB. Our finding suggests that WhiB4 is an attractive target for the development of novel therapeutics, which may help to prevent the reactivation of latent infection, thereby reducing the incidences of active TB.

Funder

National Key Research and Development Program of China

Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00443-21

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