Plasmodium falciparum GAP40 Plays an Essential Role in Merozoite Invasion and Gametocytogenesis

Author:

He Lu1,Qiu Yue12,Pang Geping1,Li Siqi1,Wang Jingjing1,Feng Yonghui34,Chen Lumeng1,Zhu Liying1,Liu Yinjie1,Cui Liwang5ORCID,Cao Yaming1ORCID,Zhu Xiaotong1ORCID

Affiliation:

1. Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China

2. Department of Cardiovascular Ultrasound, The First Hospital of China Medical University, Shenyang, Liaoning, China

3. Department of Laboratory Medicine, the First Hospital of China Medical University, Shenyang, Liaoning, China

4. National Clinical Research Center for Laboratory Medicine, Shenyang, Liaoning, China

5. College of Public Health, University of South Florida, Tampa, Florida, USA

Abstract

Red blood cell invasion is central to the pathogenesis of the malaria parasite, and the parasite proteins involved in this process are potential therapeutic targets. Gliding motility powers merozoite invasion and is driven by a unique molecular motor termed the glideosome.

Funder

MOST | National Natural Science Foundation of China

Department of Science and Technology of Liaoning Province

Nagasaki University

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference89 articles.

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