Pathogen Detection Using Metagenomic Next-Generation Sequencing of Plasma Samples from Patients with Sepsis in Uganda-Reference-Cited by-同舟云学术

Pathogen Detection Using Metagenomic Next-Generation Sequencing of Plasma Samples from Patients with Sepsis in Uganda

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Grundy Brian S.¹^ORCID,Parikh Hardik¹,Jacob Shevin²,Banura Patrick³,Moore Chris C.¹,Liu Jie⁴^ORCID,Houpt Eric R.¹^ORCID

Affiliation:

1. Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA

2. Liverpool School of Tropical Medicine, Liverpool, United Kingdom

3. Ministry of Health, National Disease Control Department, Kampala, Uganda

4. School of Public Health, Qingdao University, Qingdao, China

Abstract

The use of next-generation sequencing (NGS) in blood samples is an emerging technology for clinical microbiology labs. In this work, we performed NGS on plasma samples from a well-characterized cohort, where all samples had been previously tested by PCR for 43 pathogens.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04312-22

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