Replication-Deficient Zika Vector-Based Vaccine Provides Maternal and Fetal Protection in Mouse Model

Author:

Garcia Gustavo1ORCID,Chakravarty Nikhil2ORCID,Abu Angel Elma3,Jeyachandran Arjit Vijey1,Takano Kari-Ann45,Brown Rebecca6,Morizono Kouki45,Arumugaswami Vaithilingaraja178ORCID

Affiliation:

1. Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA

2. Department of Epidemiology, University of California, Los Angeles, Los Angeles, California, USA

3. Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California, USA

4. Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA

5. AIDS Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA

6. Departments of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA

7. Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, California, USA

8. California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California, USA

Abstract

This research is important as it strives to address the critical need for effective prophylactic measures against the outbreak of Zika virus (ZIKV) and outlines an important vaccine technology that could potentially be used to induce immune responses against other pandemic-potential viruses.

Funder

HHS | NIH | National Eye Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

California Institute for Regenerative Medicine

HHS | NIH | Office of AIDS Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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