Diagnostic Accuracy of Point of Care Cryptococcal Antigen Lateral Flow Assay in Fingerprick Whole Blood and Urine Samples for the Detection of Asymptomatic Cryptococcal Disease in Patients with Advanced HIV Disease

Author:

Boyd Kathryn12,Kouamou Vinie12ORCID,Hlupeni Admire1,Tangwena Zorodzai12,Ndhlovu Chiratidzo E.12,Makadzange Azure T.1ORCID,

Affiliation:

1. Charles River Medical Group, Harare, Zimbabwe

2. Unit of Internal Medicine, Department of Primary Health Care Sciences, University of Zimbabwe, Harare, Zimbabwe

Abstract

Cryptococcal disease (CD) remains a leading cause of morbidity and mortality among individuals with advanced HIV disease (AHD). Identifying point of care (POC) approaches to screening for CD in asymptomatic individuals is important to guide therapeutic management.

Funder

HHS | Centers for Disease Control and Prevention

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference29 articles.

1. World Health Organization. 2017. Managing advanced HIV disease and rapid initiation of antiretroviral therapy. WHO, Geneva, Switzerland.

2. Concurrent advanced HIV disease and viral load suppression in a high-burden setting: Findings from the 2015–6 ZIMPHIA survey

3. World Health Organization. 2018. Guidelines for the diagnosis, prevention, and management of cryptococcal disease in HIV-infected adults, adolescents and children, March 2018: supplement to the 2016 consolidated guidelines of the use of antiretroviral drugs for treating and preventing HIV infection. WHO, Geneva, Switzerland.

4. Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa

5. Key highlights from the international AIDS society (IAS) conference 2021

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