Neutralizing Monoclonal Antibodies Inhibit SARS-CoV-2 Infection through Blocking Membrane Fusion-Reference-Cited by-同舟云学术

Neutralizing Monoclonal Antibodies Inhibit SARS-CoV-2 Infection through Blocking Membrane Fusion

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Li Chia-Jung¹,Chao Tai-Ling²³,Chang Ting-Yu¹,Hsiao Chia-Chun¹,Lu De-Chao¹,Chiang Yi-Wei¹,Lai Guan-Chun¹,Tsai Ya-Min²,Fang Jun-Tung²,Ieong Siman²,Wang Jann-Tay⁴,Chang Sui-Yuan²⁵,Chang Shih-Chung¹⁶^ORCID

Affiliation:

1. Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei, Taiwan

2. Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan

3. Genomics Research Center, Academia Sinica, Taipei, Taiwan

4. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

5. Department of Laboratory Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan

6. Center of Biotechnology, National Taiwan University, Taipei, Taiwan

Abstract

The spike (S) protein on the surface of SARS-CoV-2 mediates receptor binding and virus-host cell membrane fusion during virus entry. Many neutralizing antibodies (nAbs), which targeted the receptor binding domain (RBD) of S protein, lost the neutralizing activity against the newly emerging SARS-CoV-2 variants with sequence mutations at the RBD.

Funder

Ministry of Science and Technology, Taiwan

National Taiwan University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01814-21

Reference54 articles.

1. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

2. Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies