Broad-Spectrum Inhibitors against Class A, B, and C Type β-Lactamases to Block the Hydrolysis against Antibiotics: Kinetics and Structural Characterization-Reference-Cited by-同舟云学术

Broad-Spectrum Inhibitors against Class A, B, and C Type β-Lactamases to Block the Hydrolysis against Antibiotics: Kinetics and Structural Characterization

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Farhat Nabeela¹,Gupta Divya¹²,Ali Abid¹,Kumar Yogesh³,Akhtar Farheen¹,Kulanthaivel Senthilguru⁴,Mishra Prashant⁴,Khan Feroz³,Khan Asad U.¹^ORCID

Affiliation:

1. Medical Microbiology and Molecular Biology Lab, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

2. Department of Life Sciences, Uttarakhand Technical University, Dehradun, Uttarakhand, India

3. CSIR-Central Institute of Medicinal & Aromatic Plants, CIMAP, Lucknow, Uttar Pradesh, India

4. Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, New Delhi, Delhi, India

Abstract

Several inhibitors for usage in conjunction with antibiotics have been developed. However, to date, there is no commercially available broad-spectrum β-lactamase inhibitor that targets both MBLs and SBLs.

Funder

Department of Biotechnology, Ministry of Science and Technology, India

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00450-22

Reference41 articles.

1. Three Decades of β-Lactamase Inhibitors

2. Updated Functional Classification of β-Lactamases

3. Novel Antimicrobial Agents Against Multi-drug-resistant Gram-negative Bacteria: An Overview