Mixed T Helper1/T Helper2/T Cytotoxic Profile in Subjects with Chronic Chagas Disease with Hypersensitivity Reactions to Benznidazole-Reference-Cited by-同舟云学术

Mixed T Helper1/T Helper2/T Cytotoxic Profile in Subjects with Chronic Chagas Disease with Hypersensitivity Reactions to Benznidazole

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Castro Eiro Melisa D.¹²,Natale María A.²,Alvarez María G.¹^ORCID,Castro Araceli³,Seigelshifer Débora¹,Viotti Rodolfo¹,Fernández Marisa²^ORCID,Mazzuoccolo Luis¹,Lococo Bruno¹,Bertocchi Graciela L.¹,Cesar Gonzalo²,Albareda María C.²,Elias María J.²,Caputo María B.²,Gaddi Eduardo⁴,Balbaryski Jeanette⁴,Vigliano Carlos A.³,Laucella Susana A.¹²^ORCID

Affiliation:

1. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires, Argentina

2. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben, Buenos Aires, Argentina

3. Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Buenos Aires, Argentina

4. Hospital Pedro de Elizalde, Buenos Aires, Argentina

Abstract

This study identified the risk factors for the development of adverse reactions to benznidazole and identified a set molecule to monitor the appearance of these reactions. This knowledge might improve the safety of benznidazole administration.

Funder

HHS | National Institutes of Health

MINCyT | ANPCyT | Fondo para la Investigación Científica y Tecnológica

Consejo Nacional de Investigaciones Científicas y Técnicas

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01357-22

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