Phenotypic and Molecular Characterization of an Enterobacter ludwigii Clinical Isolate Carrying a Plasmid-Mediated <i>bla</i> <sub>IMI-6</sub> Gene-Reference-Cited by-同舟云学术

Phenotypic and Molecular Characterization of an Enterobacter ludwigii Clinical Isolate Carrying a Plasmid-Mediated bla _IMI-6 Gene

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Blanco-Martín T.¹²,Guzmán-Puche J.¹²³,Riazzo C.¹²,Gasca-Santiyán M.¹²,Hernández-García M.³⁴^ORCID,Cantón R.³⁴,Torre-Cisneros J.²³⁵⁶^ORCID,Herrera C.²⁷,Martínez-Martínez L.¹²³⁸^ORCID

Affiliation:

1. Microbiology Unit, Reina Sofía University Hospital, Cordoba, Spain

2. Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain

3. CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain

4. Microbiology Unit, Ramón y Cajal University Hospital and Ramón y Cajal Institute for Health Reasearch (IRICYS), Madrid, Spain

5. Infectious Diseases Unit, Reina Sofía University Hospital, Cordoba, Spain

6. Medical and Surgical Sciences Department, University of Cordoba, Cordoba, Spain

7. Haematology Department, Reina Sofía University Hospital, Cordoba, Spain

8. Agricultural Chemistry, Soil Science and Microbiology Department, University of Cordoba, Cordoba, Spain

Abstract

IMI carbapenemases confer an unusual resistance pattern of susceptibility to broad-spectrum cephalosporins and piperacillin-tazobactam but decreased susceptibility to carbapenems, which may make them difficult to detect in routine practice. Commercially available molecular methods for the detection of carbapenemases in clinical laboratories do not usually include bla IMI genes, which could contribute to the hidden dissemination of bacteria producing these enzymes.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04620-22

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