Phylogenetic Analysis with Prediction of Cofactor or Ligand Binding for Pseudomonas aeruginosa PAS and Cache Domains

Author:

Hutchin Andrew1234,Cordery Charlotte1235,Walsh Martin A.23,Webb Jeremy S.15,Tews Ivo15ORCID

Affiliation:

1. Biological Sciences, Institute for Life Sciences, University of Southampton, Southampton, United Kingdom

2. Diamond Light Source, Harwell Science and Innovation Campus, Didcot, United Kingdom

3. Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, United Kingdom

4. Structure and Function of Biological Membranes Lab, Université Libre de Bruxelles, Brussels, Belgium

5. National Biofilms Innovation Centre, University of Southampton, Southampton, United Kingdom

Abstract

To adjust to a variety of life conditions, bacteria typically use multidomain proteins, where the modular structure allows functional differentiation. Proteins responding to environmental cues and regulating physiological responses are found in chemotaxis pathways that respond to a wide range of stimuli to effect movement.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

Diamond Light Source

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference200 articles.

1. Pseudomonas aeruginosa: Assessment of Risk from Drinking Water

2. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen

3. World Health Organization. 2017. WHO publishes list of bacteria for which new antibiotics are urgently needed. World Health Organization Geneva Switzerland. http://www.who.int/mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/.

4. Lung Infections Associated with Cystic Fibrosis

5. Pseudomonaschemotaxis

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