Morning SARS-CoV-2 Testing Yields Better Detection of Infection Due to Higher Viral Loads in Saliva and Nasal Swabs upon Waking-Reference-Cited by-同舟云学术

Morning SARS-CoV-2 Testing Yields Better Detection of Infection Due to Higher Viral Loads in Saliva and Nasal Swabs upon Waking

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Viloria Winnett Alexander¹^ORCID,Porter Michael K.¹^ORCID,Romano Anna E.¹^ORCID,Savela Emily S.¹^ORCID,Akana Reid¹^ORCID,Shelby Natasha¹^ORCID,Reyes Jessica A.¹^ORCID,Schlenker Noah W.¹^ORCID,Cooper Matthew M.¹^ORCID,Carter Alyssa M.¹^ORCID,Ji Jenny¹^ORCID,Barlow Jacob T.¹^ORCID,Tognazzini Colten²,Feaster Matthew²^ORCID,Goh Ying-Ying²^ORCID,Ismagilov Rustem F.¹^ORCID

Affiliation:

1. California Institute of Technology, Pasadena, California, USA

2. City of Pasadena Public Health Department, Pasadena, California, USA

Abstract

Our findings suggest that collecting saliva and nasal swab specimens in the morning immediately after waking yields higher SARS-CoV-2 viral loads than collection later in the day. The higher viral loads from morning specimen collection are predicted to significantly improve detection of SARS-CoV-2 in symptomatic individuals, particularly when using moderate- to low-analytical-sensitivity COVID-19 diagnostic tests, such as rapid antigen tests.

Funder

Jacobs Institute for Molecular Engineering for Medicine

DGSOM Geffen Fellowship

Ronald and Maxine Linde Center for New Initiatives

Caltech graduate student fellowship

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03873-22