A Novel and Efficient Platform for Discovering Noncanonical Quorum-Quenching Proteins

Author:

Liao Jinxing1,Li Zihan1,Xiong Dan1,Shen Danyu1,Wang Lu2,Shao Xiaolong1,Li Tao3,Qian Guoliang1ORCID

Affiliation:

1. College of Plant Protection, Laboratory of Plant Immunity, Key Laboratory of Integrated Management of Crop Diseases and Pests, Nanjing Agricultural University, Nanjing, Jiangsu, People’s Republic of China

2. Medical College, China Three Gorges University, Yichang, People’s Republic of China

3. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, People’s Republic of China

Abstract

Targeting and blocking bacterial quorum sensing (QS), the process known as quorum quenching (QQ) is an effective mean to control bacterial infection and overcome the emerging antibiotic resistance. Previously, diverse QS signal-degradation enzymes are identified as canonical QQ proteins.

Funder

National Natural Science Foundation of China

MOE | Fundamental Research Funds for the Central Universities

Natural Science Foundation of Jiangsu Province

Jiangsu University Advantage Discipline Construction Project

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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